The hottest polyurethane coating used in antibacte

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Polyurethane coating is used for antibacterial catheter, which helps to prevent infection

polyurethane coating is used for antibacterial catheter, which helps to prevent infection

March 11, 2019

researchers at Brown University developed a new antibacterial coating for intravascular catheter, which one day can help to prevent catheter-related bloodstream infection, which is the most common type of hospital infection

Anita Shukla, assistant professor of engineering at Brown University and author of a new paper describing the work, said: "such infections are a major burden on hospitals, health care providers and most patients." We want to develop a coating Chinese paint that can not only kill floating (free floating) bacteria, but also prevent bacteria from colonizing the surface. The preliminary data we collected shows that we have some very promising things. "

in this paper, researchers showed that polyurethane coating can be easily applied to various medical related surfaces, and gradually release a drug called jinnofen, which can kill methicillin-resistant Staphylococcus aureus (MRSA) bacteria for nearly a month in laboratory tests. The test also shows that the coating can prevent the formation of MRSA biofilm, and the antibacterial treatment is particularly effective

this study was published in the "frontier of cell and infection Microbiology". Shukla's laboratory at Brown Institute of Engineering cooperated with Eleftherios mylonakis and Beth fuc2 of infectious diseases department of Warren Alpert Medical College in brown. The accuracy indicators of environmental parameters in the working chamber of the climate box [such as temperature, humidity, salt fog sedimentation rate, etc.] are the results of detection under no-load condition. HS laboratory

"this is a perfect cooperation between medicine and engineering," Shukla said of the partnership. They (mylonakis and Fuchs) asked us about the types of problems they often have in the clinic. As an engineering laboratory focusing on the development of new drug delivery biomaterials, we can find engineering solutions to the problems they have brought us. "

the problem of this matter is very prominent. In the United States alone, more than 150million people are implanted with intravascular catheters every year, and 250000 people are infected by implants every year. These infections are fatal in up to 25% of cases, and even if successfully treated, prolonged hospitalization can add millions of dollars

researchers say that previous methods to solve this problem have achieved limited success. Other antibacterial coatings tend to fail after up to two weeks, usually because they release drugs too quickly. Other coatings also tend to use traditional antibiotics, which has raised concerns about the long-term use of antibiotic resistance

for their new coating, SH processability ukla and colleagues used jinnofen. This drug was originally developed and approved by the U.S. Food and Drug Administration for the treatment of arthritis, but studies by mylonakis, Fuchs and others have shown that this drug is also very effective in killing methicillin-resistant Staphylococcus aureus and other dangerous microorganisms. In addition, the way it works makes it difficult for bacteria to form a natural resistance. Jinnofen has never been used in coating technology before

in order to make the coating, the researchers dissolved polyurethane and genofen in the solution, and then placed the solution on the catheter. The solvent is then evaporated, leaving a stretchable but durable polymer coating. Mechanical tests show that the coating can be stretched to 500% without fracture

in order to test the effectiveness of the coating, the researchers placed the coated catheter on the growth solution of methicillin-resistant Staphylococcus aureus and agar plate. Experiments show that the coating can inhibit the growth of MRSA for 26 days, which depends on the initial concentration of kinofofen used in the coating. Researchers also used bioluminescence imaging technology to look for signs of biofilm formation. These experiments show that the coating can prevent any traces of biofilm. For comparison, the researchers also tested a catheter with a more traditional antibiotic, which is very effective against free floating methicillin-resistant Staphylococcus aureus, but it has proved that it cannot prevent the formation of biofilm

shukla said: "biofilm has a way to effectively enhance the core competitiveness of enterprises to avoid antibiotics. Compared with planktonic bacteria, the formation of bacterial biofilm makes drug treatment more difficult thousands of times. In fact, these coatings can prevent the formation of biofilm first, which is very important."

Shukla said that preliminary toxicity tests in the laboratory showed that the coating had no adverse effects on human blood or liver cells, but more tests were needed before the coating was ready for use in patients. The fact that the ingredients of both coatings have been approved by FDA for other uses should speed up the approval process for in vivo testing

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